Harriet Beecher Stowe's anti-slavery serial, Uncle Tom's Cabin, or Life Among the Lowly, starts a ten-month run in the National Era abolitionist newspaper.

Harriet Elisabeth Beecher Stowe was an American author and abolitionist. She came from the religious Beecher family and wrote the popular novel Uncle Tom's Cabin (1852), which depicts the harsh conditions experienced by enslaved African Americans. The book reached an audience of millions as a novel and play, and became influential in the United States and in Great Britain, energizing anti-slavery forces in the American North, while provoking widespread anger in the South. Stowe wrote 30 books, including novels, three travel memoirs, and collections of articles and letters. She was influential both for her writings as well as for her public stances and debates on social issues of the day.

Slavery is the ownership of a person as property, especially in regards to their labour. It is an economic phenomenon and its history resides in economic history. Slavery typically involves compulsory work, with the slave's location of work and residence dictated by the party that holds them in bondage. Enslavement is the placement of a person into slavery, and the person is called a slave or an enslaved person.

Uncle Tom's Cabin; or, Life Among the Lowly is an anti-slavery novel by American author Harriet Beecher Stowe. Published in two volumes in 1852, the novel had a profound effect on attitudes toward African Americans and slavery in the U.S., and is said to have "helped lay the groundwork for the American Civil War".

In the United States, abolitionism, the movement that sought to end slavery in the country, was active from the colonial era until the American Civil War, the end of which brought about the abolition of American slavery, except as punishment for a crime, through the Thirteenth Amendment to the United States Constitution.