Space Shuttle Endeavour launches on STS-111, carrying the Expedition 5 crew to the International Space Station to replace the Expedition 4 crew. Astronaut Franklin Chang-Díaz becomes the second person to have flown on seven spaceflights.

Space Shuttle Endeavour is a retired orbiter from NASA's Space Shuttle program and the fifth and final operational Shuttle built. It embarked on its first mission, STS-49, in May 1992 and its 25th and final mission, STS-134, in May 2011. STS-134 was expected to be the final mission of the Space Shuttle program, but with the authorization of STS-135 by the United States Congress, Atlantis became the last shuttle to fly.

STS-111 was a space shuttle mission to the International Space Station (ISS) flown by Space Shuttle Endeavour. STS-111 resupplied the station and replaced the Expedition 4 crew with the Expedition 5 crew. It was launched on 5 June 2002, from Kennedy Space Center, Florida.

Expedition 5 was the fifth long-duration stay on the International Space Station (ISS). The crew, consisting of three people, remained in space for 184 days, 178 of which were spent aboard the ISS. Expedition 5 was a continuation of an uninterrupted human presence in space, as of November 2000, which was begun by Expedition 1 in 2000–2001.

The International Space Station (ISS) is a large space station that was assembled and is maintained in low Earth orbit by a collaboration of five space agencies and their contractors: NASA, Roscosmos (Russia), ESA (Europe), JAXA (Japan), and CSA (Canada). As the largest space station ever constructed, it primarily serves as a platform for conducting scientific experiments in microgravity and studying the space environment.