War of the League of Cambrai: Milanese forces with Swiss mercenaries defeated the French in Novara, forcing them to withdraw from the Duchy of Milan and Italy.

The War of the League of Cambrai, also known by its second stage as the War of the Holy League, was fought from February 1508 to December 1516, as part of the wider Italian Wars of 1494–1559. The main participants of the war, who fought for its entire duration, were France, the Papal States, and the Republic of Venice; they were joined at various times by nearly every significant power in Western Europe, including the Holy Roman Empire, Spain, England, the Duchy of Milan, the Republic of Florence, the Duchy of Ferrara, and the Swiss.

The Swiss mercenaries were a powerful infantry force constituting professional soldiers originating from the cantons of the Old Swiss Confederacy. They were notable for their service in foreign armies, especially among the military forces of the kings of France, throughout the early modern period of European history, from the Late Middle Ages into the 19th century. Their service as mercenaries was at its peak during the Renaissance, when their proven battlefield capabilities made them sought-after mercenary troops. There followed a period of decline, as technological and organizational advances counteracted the Swiss' advantages. Switzerland's military isolationism largely put an end to organized mercenary activity; the principal remnant of the practice is the Pontifical Swiss Guard at the Vatican.

The Battle of Novara was a battle of the War of the League of Cambrai fought on 6 June 1513, near Novara, in Northern Italy. A French attacking force was routed by allied Milanese–Swiss troops. As a consequence, France was forced to withdraw entirely from Italy.

Novara is the capital city of the province of Novara in the Piedmont region in northwest Italy, to the west of Milan. With 101,916 inhabitants, it is the second most populous city in Piedmont after Turin. It is an important crossroads for commercial traffic along the routes from Milan to Turin and from Genoa to Switzerland. Novara lies between the streams Agogna and Terdoppio in northeastern Piedmont, 50 km (31 mi) from Milan and 95 km (59 mi) from Turin. It is only 15 km (9.3 mi) distant from the river Ticino, which marks the border with Lombardy region.