After establishing the city of Santo Domingo, Christopher Columbus departs for Spain, leaving his brother in command.

Santo Domingo, formerly known as Santo Domingo de Guzmán, is the capital and largest city of the Dominican Republic and the largest metropolitan area in the Caribbean by population. As of 2022, the city center had a population of 1,029,110 while its metropolitan area, Greater Santo Domingo, had a population of 4,274,651. The city is coterminous with the boundaries of the Distrito Nacional (D.N.), itself bordered on three sides by Santo Domingo Province.

Christopher Columbus was an Italian explorer and navigator from the Republic of Genoa who completed four Spanish-based voyages across the Atlantic Ocean sponsored by the Catholic Monarchs, opening the way for the widespread European exploration and colonization of the Americas. His expeditions were the first known European contact with the Caribbean and Central and South America.

March 10 is the 69th day of the year in the Gregorian calendar; 296 days remain until the end of the year.