A large fire destroyed 856 of the 1,100 structures in New Orleans.

The Great New Orleans Fire (1788) was a fire that destroyed 856 of the 1,100 structures in New Orleans, Louisiana, on March 21, 1788, spanning the south central Vieux Carré from Burgundy to Chartres Street, almost to the Mississippi River front buildings. An additional 212 buildings were destroyed in a later citywide fire on December 8, 1794.

New Orleans is a consolidated city-parish located along the Mississippi River in the U.S. state of Louisiana. With a population of 383,997 at the 2020 census, New Orleans is the most populous city in Louisiana, the second-most populous in the Deep South after Atlanta, and the twelfth-most populous in the Southeastern United States; the New Orleans metropolitan area with about 1 million residents is the 59th-most populous metropolitan area in the nation. New Orleans serves as a major port and commercial hub for the broader Gulf Coast region. The city is coextensive with Orleans Parish.