China Eastern Airlines Flight 5735 crashes in Guangxi, China, killing 132 people.

China Eastern Airlines Flight 5735 (MU5735) was a domestic passenger flight from Kunming Changshui International Airport to its planned destination, Guangzhou Baiyun International Airport in China. At 14:23 China Standard Time on 21 March 2022, the Boeing 737-89P aircraft descended steeply mid-flight and struck the ground at high speed in Teng County, Wuzhou, Guangxi, killing all 132 passengers and crew on board. It is the third deadliest aviation accident in China, the deadliest in the history of China Eastern Airlines, and the deadliest plane crash in 2022. The Civil Aviation Administration of China (CAAC) is responsible for the investigation.

Guangxi, officially the Guangxi Zhuang Autonomous Region, is an autonomous region of the People's Republic of China, located in South China and bordering Vietnam and the Gulf of Tonkin. Formerly a province, Guangxi became an autonomous region in 1958. Its current capital is Nanning.

March 21 is the 80th day of the year in the Gregorian calendar; 285 days remain until the end of the year.