The appointment of Mehmed Reshid as governor of Diyarbekir, Turkey intensified the genocide of Syriac Christians by pro-Ottoman forces.

Mehmed Reshid was an Ottoman politician and physician, official of the Committee of Union and Progress, and governor of the Diyarbekir Vilayet (province) of the Ottoman Empire during World War I. He is known for organizing the 1915 genocide of the Armenian and Assyrian communities of Diyarbekir, in which between 144,000 and 157,000 Armenians, Assyrians, and other Christians were killed. During the Allied occupation of Istanbul, Reshid was arrested and his roles in the massacres were exposed. He later escaped from prison, but committed suicide after being cornered by local authorities.

The Vilayet of Diyâr-ı Bekr was a first-level administrative division (vilayet) of the Ottoman Empire, wholly located within what is now modern Turkey. The vilayet extended south from Palu on the Euphrates to Mardin and Nusaybin on the edge of the Mesopotamian plain. After the establishment of Republic of Turkey in 1923, the region was incorporated into the newly created state.

The Sayfo, also known as the Seyfo or the Assyrian genocide, was the mass murder and deportation of Assyrian/Syriac Christians in southeastern Anatolia and Persia's Azerbaijan province by Ottoman forces and some Kurdish tribes during World War I.

The Ottoman Empire, also called the Turkish Empire, was an imperial realm that controlled much of Southeast Europe, West Asia, and North Africa from the 14th to early 20th centuries; it also controlled parts of southeastern Central Europe, between the early 16th and early 18th centuries.