Diocletian and Maximian retired as co-rulers of the Roman Empire, being succeeded by Galerius and Constantius Chlorus.

Diocletian, nicknamed Jovius, was Roman emperor from 284 until his abdication in 305. He was born Diocles to a family of low status in the Roman province of Dalmatia. As with other Illyrian soldiers of the period, Diocles rose through the ranks of the military early in his career, serving under Aurelian and Probus, and eventually becoming a cavalry commander for the army of Emperor Carus. After the deaths of Carus and his son Numerian on a campaign in Persia, Diocles was proclaimed emperor by the troops, taking the name "Diocletianus". The title was also claimed by Carus's surviving son, Carinus, but Diocletian defeated him in the Battle of the Margus.

Maximian, nicknamed Herculius, was Roman emperor from 286 to 305. He was Caesar from 285 to 286, then Augustus from 286 to 305. He shared the latter title with his co-emperor and superior, Diocletian, whose political brain complemented Maximian's military brawn. Maximian established his residence at Trier but spent most of his time on campaign. In late 285, he suppressed rebels in Gaul known as the Bagaudae. From 285 to 288, he fought against Germanic tribes along the Rhine frontier. Together with Diocletian, he launched a scorched earth campaign deep into Alamannic territory in 288, refortifying the frontier.

The Roman Empire ruled the Mediterranean and much of Europe, Western Asia and North Africa. The Romans conquered most of this during the Republic, and it was ruled by emperors following Octavian's assumption of effective sole rule in 27 BC. The western empire collapsed in 476 AD, but the eastern empire lasted until the fall of Constantinople in 1453.

Galerius Valerius Maximianus was Roman emperor from 305 to 311. He participated in the system of government later known as the Tetrarchy, first acting as caesar under Emperor Diocletian. In this period Galerius obtained victory warring against the Persian Sassanian Empire, defeating Narseh at the battle of Satala in 298 and possibly sacking the Sassanian capital of Ctesiphon in 299. He also campaigned across the Danube against the Carpi, defeating them in 297 and 300. Galerius was promoted to augustus upon the abdication of Diocletian in 305, but had to contend with multiple usurpers as the Tetrarchic system broke down. Although he was a staunch opponent of Christianity, he ended the Diocletianic Persecution by issuing the Edict of Serdica in 311.