Amerigo Vespucci allegedly leaves Cádiz for his first voyage to the New World.

Amerigo Vespucci was an Italian explorer, navigator and popular author from the Republic of Florence for whom "America" is named.

Cádiz is a city in Spain and the capital of the Province of Cádiz in the autonomous community of Andalusia. It is located in the southwest of the Iberian Peninsula off the Atlantic Ocean separated from neighbouring San Fernando by a narrow isthmus. One of the oldest continuously inhabited cities in Western Europe, Cádiz was founded by the Phoenicians as a trading post. In the 18th century, the Port in the Bay of Cádiz consolidated as the main harbour of mainland Spain, enjoying the virtual monopoly of trade with the Americas until 1778. It is also the site of the University of Cádiz.

The "New World" is a eurocentric term used to describe the majority of lands of Earth's Western Hemisphere, particularly the Americas, and sometimes Oceania. The term arose in the early 16th century during Europe's colonization period, after Italian explorer Amerigo Vespucci published the Latin-language pamphlet Mundus Novus, presenting his conclusion that the lands to the west of the Atlantic Ocean constitute new continents.

May 10 is the 130th day of the year in the Gregorian calendar; 235 days remain until the end of the year.