A report by the Surgeon General of the United States C. Everett Koop states that the addictive properties of nicotine are similar to those of heroin and cocaine.

The surgeon general of the United States is the operational head of the United States Public Health Service Commissioned Corps (PHSCC) and thus the leading spokesperson on matters of public health in the federal government of the United States. The surgeon general's office and staff are known as the Office of the Surgeon General (OSG), which is housed within the Office of the Assistant Secretary for Health.

Charles Everett Koop was an American pediatric surgeon and public health administrator who served as the 13th surgeon general of the United States under President Ronald Reagan from 1982 to 1989. According to the Associated Press, "Koop was the only surgeon general to become a household name" due to his frequent public presence around the HIV/AIDS crisis of the 1980s.

Substance use disorder (SUD) is the persistent use of drugs despite substantial harm and adverse consequences to self and others. Related terms include substance use problems and problematic drug or alcohol use. Along with substance-induced disorders (SID) they are encompassed in the category substance-related disorders.

Nicotine is a naturally produced alkaloid in the nightshade family of plants and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits where it acts as a receptor antagonist.