Fall of Acre, the end of Crusader presence in the Holy Land.

The siege of Acre took place in 1291 and resulted in the Crusaders' losing control of Acre to the Mamluks. It is considered one of the most important battles of the period. Although the crusading movement continued for several more centuries, the capture of the city marked the end of further crusades to the Levant. When Acre fell, the Crusaders lost their last major stronghold of the Crusader Kingdom of Jerusalem.

The Crusader states, or Outremer, were four Catholic polities established in the Levant region and southeastern Anatolia from 1098 to 1291. Following the principles of feudalism, the foundation for these polities was laid by the First Crusade, which was proclaimed by the Latin Church in 1095 in order to reclaim the Holy Land after it was lost to the 7th-century Muslim conquest. From north to south, they were: the County of Edessa (1098–1150), the Principality of Antioch (1098–1268), the County of Tripoli (1102–1289), and the Kingdom of Jerusalem (1099–1291).

The term "Holy Land" is used to collectively denote areas of the Southern Levant that hold great significance in the Abrahamic religions, primarily because of their association with people and events featured in the Bible. It is traditionally synonymous with what is known as the Land of Israel (Zion) or the Promised Land in a biblical or religious context, or as Canaan or Palestine in a secular or geographic context—referring to a region that is mostly between the Mediterranean Sea and the Jordan River. Today, it chiefly overlaps with the combined territory of the modern states of Israel and Palestine. Most notable among the religions that tie substantial spiritual value to the Holy Land are Judaism, Christianity, and Islam.