Nineteen people are killed in a plane crash in Wilkes-Barre, Pennsylvania.

On May 21, 2000, a British Aerospace BAe-3101 Jetstream 3101 operated by East Coast Aviation Services crashed into mountainous terrain in Bear Creek Township, Wilkes-Barre, Pennsylvania. The plane was carrying 17 professional gamblers returning home from Caesar's Palace Casino in Atlantic City, New Jersey, along with 2 crew members. It was chartered by Caesar's Palace. All 19 passengers and crews on board were killed on impact. This accident, alongside the accident of Aerocaribe Flight 7831 were the accidents with the most fatalities involving the Jetstream 3101 airliner.

Wilkes-Barre is a city in Luzerne County, Pennsylvania, United States, and its county seat. Located along the Susquehanna River in Northeastern Pennsylvania, it had a population of 44,328 in the 2020 census. It is part of the Wyoming Valley metropolitan area, which includes five cities and more than 40 boroughs forming a contiguous urban corridor with an estimated 574,000 residents. Wilkes-Barre is located 49 miles (79 km) north-northwest of Allentown, 97 miles (156 km) north-northwest of Philadelphia, and 106 miles (171 km) west-northwest of New York City.

May 21 is the 141st day of the year in the Gregorian calendar; 224 days remain until the end of the year.