Dong Zhuo is assassinated by his adopted son Lü Bu.

Dong Zhuo, courtesy name Zhongying, was a Chinese military general, politician, and warlord who lived in the late Eastern Han dynasty. At the end of the reign of the Eastern Han, Dong Zhuo was a general and powerful minister of the imperial government. Originally from Liang Province, Dong Zhuo seized control of the imperial capital Luoyang in 189 when it entered a state of turmoil following the death of Emperor Ling of Han and a massacre of the eunuch faction by the court officials led by General-in-Chief He Jin.

Lü Bu, courtesy name Fengxian, was a Chinese military general, politician, and warlord who lived during the late Eastern Han dynasty of Imperial China. Originally a subordinate of a minor warlord Ding Yuan, he betrayed and murdered Ding Yuan and defected to Dong Zhuo, the warlord who controlled the Han central government in the early 190s. In 192, he turned against Dong Zhuo and killed him after being instigated by Wang Yun and Shisun Rui (士孙瑞), but was later defeated and driven away by Dong Zhuo's followers.

May 22 is the 142nd day of the year in the Gregorian calendar; 223 days remain until the end of the year.