In Florida, Hernando de Soto lands at Tampa Bay with 600 soldiers with the goal of finding gold.

Florida is a state in the Southeastern region of the United States. It borders the Gulf of Mexico to the west, Alabama to the northwest, Georgia to the north, the Atlantic Ocean to the east, the Straits of Florida to the south, and The Bahamas to the southeast. About two-thirds of Florida occupies a peninsula between the Gulf of Mexico and the Atlantic Ocean. It has the longest coastline in the contiguous United States, spanning approximately 1,350 miles (2,170 km), not including its many barrier islands. It is the only state that borders both the Gulf of Mexico and the Atlantic Ocean. With a population of over 23 million, it is the third-most populous state in the United States and ranks seventh in population density as of 2020. Florida spans 65,758 square miles (170,310 km²), ranking 22nd in area among the states. The Miami metropolitan area, anchored by the cities of Miami, Fort Lauderdale, and West Palm Beach, is the state's largest metropolitan area, with a population of 6.138 million; the most populous city is Jacksonville. Florida's other major population centers include Tampa Bay, Orlando, Cape Coral, and the state capital of Tallahassee.

Hernando de Soto was a Spanish explorer and conquistador who was involved in expeditions in Nicaragua and the Yucatan Peninsula. He played an important role in Francisco Pizarro's conquest of the Inca Empire in Peru, but is best known for leading the first European expedition deep into the territory of the modern-day United States. He is the first European documented as having crossed the Mississippi River.

Tampa Bay is a large natural harbor and shallow estuary connected to the Gulf of Mexico on the west-central coast of Florida, comprising Hillsborough Bay, McKay Bay, Old Tampa Bay, Middle Tampa Bay, and Lower Tampa Bay. The largest freshwater inflow into the bay is the Hillsborough River, which flows into Hillsborough Bay in downtown Tampa. Many other smaller rivers and streams also flow into Tampa Bay, resulting in a large watershed area.