Led by Italian general Giuseppe Garibaldi, the volunteer Expedition of the Thousand set sail from Genoa on a campaign to conquer the Kingdom of the Two Sicilies, a crucial event of the unification of Italy.

Giuseppe Maria Garibaldi was an Italian general, revolutionary and republican. He contributed to Italian unification (Risorgimento) and the creation of the Kingdom of Italy. He is considered to be one of Italy's "fathers of the fatherland", along with Camillo Benso di Cavour, King Victor Emmanuel II and Giuseppe Mazzini. Garibaldi is also known as the "Hero of the Two Worlds" because of his military enterprises in South America and Europe.

The Expedition of the Thousand was an event of the unification of Italy that took place in 1860. A corps of volunteers led by Giuseppe Garibaldi sailed from Quarto al Mare near Genoa and landed in Marsala, Sicily, in order to conquer the Kingdom of the Two Sicilies, ruled by the Spanish House of Bourbon-Two Sicilies. The name of the expedition derives from the initial number of participants, which was around 1,000 people.

Genoa is a city in and the capital of the Italian region of Liguria, and the sixth-largest city in Italy. As of 2025, 563,947 people live within the city's administrative limits. While its metropolitan city has 818,651 inhabitants, more than 1.5 million people live in the wider metropolitan area stretching along the Italian Riviera.

The Kingdom of the Two Sicilies was a kingdom in Southern Italy from 1816 to 1861 under the control of the House of Bourbon-Two Sicilies, a cadet branch of the Bourbons. The kingdom was the largest sovereign state by population and land area in Italy before the Italian unification, comprising Sicily and most of the area of today's Mezzogiorno and covering all of the Italian peninsula south of the Papal States.