Space Shuttle program: The Space Shuttle Endeavour is launched on its first mission, STS-49.

The Space Shuttle program was the fourth human spaceflight program carried out by the U.S. National Aeronautics and Space Administration (NASA), which accomplished routine transportation for Earth-to-orbit crew and cargo from 1981 to 2011. Its official program name was Space Transportation System (STS), taken from a 1969 plan for a system of reusable spacecraft where it was the only item funded for development, as a proposed nuclear shuttle in the plan was cancelled in 1972. It flew 135 missions and carried 355 astronauts from 16 countries, many on multiple trips.

The Space Shuttle is a retired, partially reusable low Earth orbital spacecraft system operated from 1981 to 2011 by the U.S. National Aeronautics and Space Administration (NASA) as part of the Space Shuttle program. Its official program name was the Space Transportation System (STS), taken from the 1969 plan led by U.S. vice president Spiro Agnew for a system of reusable spacecraft where it was the only item funded for development.

Space Shuttle Endeavour is a retired orbiter from NASA's Space Shuttle program and the fifth and final operational Shuttle built. It embarked on its first mission, STS-49, in May 1992 and its 25th and final mission, STS-134, in May 2011. STS-134 was expected to be the final mission of the Space Shuttle program, but with the authorization of STS-135 by the United States Congress, Atlantis became the last shuttle to fly.

STS-49 was NASA's maiden flight of the Space Shuttle Endeavour, which launched on May 7, 1992. The primary goal of its nine-day mission was to retrieve an Intelsat VI satellite, Intelsat 603, which failed to leave Low Earth orbit two years before, attach it to a new upper stage, and relaunch it to its intended geosynchronous orbit. After several attempts, the capture was completed with the only three-person extravehicular activity (EVA) in space flight history. It would also stand until STS-102 in 2001 as the longest EVA ever undertaken.