Space Shuttle Columbia launches from the Kennedy Space Center on STS-5, the first operational mission of the Space Shuttle program.

Space Shuttle Columbia (OV-102) was a Space Shuttle orbiter manufactured by Rockwell International and operated by NASA. Named after the first American ship to circumnavigate the globe, and the female personification of the United States, Columbia was the first of five Space Shuttle orbiters to fly in space, debuting the Space Shuttle launch vehicle on its maiden flight on April 12, 1981 and becoming the first spacecraft to be re-used after its first flight when it launched on STS-2 on November 12, 1981. As only the second full-scale orbiter to be manufactured after the Approach and Landing Test vehicle Enterprise, Columbia retained unique external and internal features compared to later orbiters, such as test instrumentation and distinctive black chines. In addition to a heavier aft fuselage and the retention of an internal airlock throughout its lifetime, these made Columbia the heaviest of the five spacefaring orbiters: around 1,000 kilograms heavier than Challenger and 3,600 kilograms heavier than Endeavour when originally constructed. Columbia also carried ejection seats based on those from the SR-71 during its first six flights until 1983, and from 1986 onwards carried an imaging pod on its vertical stabilizer.

The John F. Kennedy Space Center, located on Merritt Island, Florida, is one of the National Aeronautics and Space Administration's (NASA) ten field centers. Since 1968, KSC has been NASA's primary launch center of American spaceflight, research, and technology. Launch operations for the Apollo, Skylab and Space Shuttle programs were carried out from Kennedy Space Center Launch Complex 39 and managed by KSC. Located on the east coast of Florida, KSC is adjacent to Cape Canaveral Space Force Station (CCSFS). The management of the two entities work very closely together, share resources, and operate facilities on each other's property.

STS-5 was the fifth NASA Space Shuttle mission and the fifth flight of the Space Shuttle Columbia. It launched on November 11, 1982, and landed five days later on November 16, 1982. STS-5 was the first Space Shuttle mission to deploy communications satellites into orbit, and the first officially "operational" Space Shuttle mission.