In New York City, American Airlines Flight 587, an Airbus A300 en route to the Dominican Republic, crashes minutes after takeoff from John F. Kennedy International Airport, killing all 260 on board and five on the ground.

American Airlines Flight 587 was a regularly scheduled international passenger flight from John F. Kennedy International Airport, New York City, to Las Américas International Airport, Santo Domingo, Dominican Republic. On November 12, 2001, the Airbus A300B4-605R flying the route crashed into the neighborhood of Belle Harbor on the Rockaway Peninsula of Queens, New York City, shortly after takeoff, killing all 251 passengers and 9 crew members aboard, as well as five people on the ground. It is the second-deadliest aviation accident to have occurred in the United States, behind the crash of American Airlines Flight 191 in 1979, and the second-deadliest aviation incident involving an Airbus A300, after Iran Air Flight 655.

The Airbus A300 is Airbus' first production aircraft and the world's first twin-engine, double-aisle (wide-body) airliner. It was developed by Airbus Industrie GIE, now merged into Airbus SE, and manufactured from 1971 to 2007.

The Dominican Republic is a country in the Caribbean located on the island of Hispaniola in the Greater Antilles of the Caribbean Sea in the North Atlantic Ocean. It shares a maritime border with Puerto Rico to the east and a land border with Haiti to the west, occupying the eastern five-eighths of Hispaniola which, along with Saint Martin, is one of only two islands in the Caribbean shared by two sovereign states. In the Antilles, the country is the second-largest nation by area after Cuba at 48,671 square kilometers (18,792 sq mi) and second-largest by population after Haiti with approximately 11.4 million people in 2024, of whom 3.6 million reside in the metropolitan area of Santo Domingo, the capital city.

John F. Kennedy International Airport is a major international airport serving New York City and its metropolitan area. JFK Airport is located on the southwestern shore of Long Island, in Queens, New York City, bordering Jamaica Bay. It is the busiest of the seven airports in the New York airport system, the sixth-busiest airport in the United States, and the busiest international commercial airport in North America. The airport, which covers 5,200 acres (2,104 ha), is the largest in the New York metropolitan area. Over 90 airlines operate from JFK Airport, with nonstop or direct flights to destinations on all six inhabited continents.