During a general strike in Guayaquil, Ecuador, police and military fired into a crowd, killing at least 300 people.

The 1922 Guayaquil general strike was a three-day general work stoppage in the city of Guayaquil, Ecuador, which lasted from 13 to 15 November of that year. The strike began with trolley, electric company and other public utility workers who were inspired by a successful strike by railroad workers in nearby Durán. Workers made demands such as pay increases, shorter hours, safer working conditions, and government control of foreign currency exchange rates.

Guayaquil, officially Santiago de Guayaquil, is the largest city in Ecuador and also the nation's economic capital and main port. The city is the capital of Guayas Province and the seat of Guayaquil Canton. The city is located on the west bank of the Guayas River, which flows into the Pacific Ocean at the Gulf of Guayaquil.