Henry VIII of England concludes the Treaty of Westminster, a pledge of mutual aid against the French, with Ferdinand II of Aragon.

Henry VIII was King of England from 22 April 1509 until his death in 1547. Henry is known for his six marriages and his efforts to have his first marriage annulled. His disagreement with Pope Clement VII about such an annulment led Henry to initiate the English Reformation, separating the Church of England from papal authority. He appointed himself Supreme Head of the Church of England and dissolved convents and monasteries, for which he was excommunicated by the pope.

The War of the League of Cambrai, also known by its second stage as the War of the Holy League, was fought from February 1508 to December 1516, as part of the wider Italian Wars of 1494–1559. The main participants of the war, who fought for its entire duration, were France, the Papal States, and the Republic of Venice; they were joined at various times by nearly every significant power in Western Europe, including the Holy Roman Empire, Spain, England, the Duchy of Milan, the Republic of Florence, the Duchy of Ferrara, and the Swiss.

Ferdinand II, also known as Ferdinand I, Ferdinand III, and Ferdinand V, called Ferdinand the Catholic, was King of Aragon from 1479 until his death in 1516. As the husband and co-ruler of Queen Isabella I of Castile, he was also King of Castile from 1475 to 1504. He reigned jointly with Isabella over a dynastically unified Spain; together they are known as the Catholic Monarchs. Ferdinand is considered the de facto first king of Spain, and was described as such during his reign, even though, legally, Castile and Aragon remained two separate kingdoms until they were formally united by the Nueva Planta decrees issued between 1707 and 1716.