A Trans World Airlines McDonnell Douglas MD-80 and Cessna 441 Conquest II aircraft collide on the runway at St. Louis Lambert International Airport in Bridgeton, Missouri, killing two people and injuring eight.

Trans World Airlines (TWA) was a trunk carrier, a scheduled airline in the United States that operated from 1930 until it was acquired by American Airlines in 2001. It was formed as Transcontinental & Western Air to operate a route from New York City to Los Angeles via St. Louis, Kansas City, and other stops, with Ford Trimotors. With American, United, and Eastern, it was one of the "Big Four" domestic airlines in the United States formed by the Spoils Conference of 1930.

The McDonnell Douglas MD-80 is a series of five-abreast single-aisle airliners developed by McDonnell Douglas. It was produced by the developer company until August 1997 and then by Boeing Commercial Airplanes. The MD-80 was the second generation of the DC-9 family, originally designated as the DC-9-80 and later stylized as the DC-9 Super 80 . Stretched, enlarged wing and powered by higher bypass Pratt & Whitney JT8D-200 engines, the aircraft program was launched in October 1977. The MD-80 made its first flight on October 18, 1979, and was certified on August 25, 1980. The first airliner was delivered to launch customer Swissair on September 13, 1980, which introduced it into service on October 10, 1980.

The Cessna 441 Conquest II is the first turboprop powered aircraft designed by Cessna and was meant to fill the gap between their jets and piston-engined aircraft. It was developed in November 1974, with the first aircraft delivered in September 1977. It is a pressurized, 8–9 passenger turbine development of the Cessna 404 Titan. The ICAO designator as used in flight plans is C441.

The 1994 St. Louis Airport collision occurred when TWA Flight 427, operated using a McDonnell Douglas MD-82, struck a Cessna 441 Conquest II during its take-off roll, killing both of its occupants. The collision took place on November 22, 1994, at St. Louis Lambert International Airport (STL) in Bridgeton, Missouri.