African slaves in the Danish West Indies began an insurrection in one of the earliest and longest slave revolts in the Americas.

The Danish West Indies or Danish Virgin Islands or Danish Antilles were a Danish colony in the Caribbean, consisting of the islands of Saint Thomas with 83 square kilometres (32 sq mi), Saint John with 49 square kilometres (19 sq mi), Saint Croix with 220 square kilometres (85 sq mi), and Water Island.

The 1733 slave insurrection on St. John or the Slave Uprising of 1733, was a slave insurrection started on Sankt Jan in the Danish West Indies on November 23, 1733, when 150 African slaves from Akwamu, in present-day Ghana, revolted against the owners and managers of the island's plantations. Led by Breffu, an enslaved woman from Ghana, and lasting several months into August 1734, the slave rebellion was one of the earliest and longest slave revolts in the Americas. The Akwamu slaves captured the fort in Coral Bay and took control of most of the island. They intended to resume crop production under their control.

A slave rebellion is an armed uprising by slaves, as a way of fighting for their freedom. Rebellions of slaves have occurred in nearly all societies that practice slavery or have practiced slavery in the past. A desire for freedom and the dream of successful rebellion is often the greatest object of song, art, and culture amongst the enslaved population. These events, however, are often violently opposed and suppressed by slaveholders.