An earthquake hits the Mediterranean destroying Beirut and Damascus and killing 30,000–40,000.

The 1759 Near East earthquakes shook a large portion of the Levant in October and November of that year. This geographical crossroads in the Eastern Mediterranean were at the time under the rule of the Ottoman Empire. The ruins of Baalbek, a settlement in the Beqaa Valley of Lebanon east of the Litani River, were badly damaged. These 1759 events, along with the earlier 1202 Syria earthquake, are likely the strongest historical earthquakes in the region.

Beirut is the capital and largest city of Lebanon. As of 2014, Greater Beirut has a population of 2.5 million, just under half of Lebanon's population, which makes it the fourth-largest city in the Levant region and the sixteenth-largest in the Arab world. The city is situated on a peninsula at the midpoint of Lebanon's Mediterranean coast. Beirut has been inhabited for more than 5,000 years, making it one of the oldest cities in the world.

Damascus is the capital and largest city of Syria. It is the oldest capital in the world and, according to some, the fourth holiest city in Islam. Known colloquially in Syria as aš-Šām (الشَّام) and dubbed, poetically, the "City of Jasmine", Damascus is a major cultural center of the Levant and the Arab world.