The Great Appalachian Storm of 1950 impacts 22 American states, killing 353 people, injuring over 160, and causing US$66.7 million in damages (1950 dollars).

The Great Appalachian Storm of November 1950 was a large extratropical cyclone which moved through the Eastern United States, causing blizzard conditions along the western slopes of the Appalachian Mountains and significant winds and heavy rainfall east of the mountains. Hurricane-force winds, peaking at 110 miles per hour (180 km/h) in Concord, New Hampshire, and 160 mph (260 km/h) in the highlands of New England, disrupted power to 1 million customers during the event.