The United States imposes economic sanctions against Sudan in response to its human rights abuses of its own citizens and its material and political assistance to Islamic extremist groups across the Middle East and East Africa.

Economic sanctions or embargoes are commercial and financial penalties applied by states or institutions against states, groups, or individuals. Economic sanctions are a form of coercion that attempts to get an actor to change its behavior through disruption in economic exchange. Sanctions can be intended to compel or deter.

Sudan, officially the Republic of Sudan, is a country in Northeast Africa. It borders the Central African Republic to the southwest, Chad to the west, Libya to the northwest, Egypt to the north, the Red Sea to the east, Eritrea and Ethiopia to the southeast, and South Sudan to the south. Sudan has a population of 50 million people as of 2024 and occupies 1,886,068 square kilometres, making it Africa's third-largest country by area. Sudan's capital and most populous city is Khartoum.

Sudan's human rights record has been widely condemned. Some human rights organizations have documented a variety of abuses and atrocities carried out by the Sudanese government over the past several years under the rule of Omar al-Bashir. The 2009 Human Rights Report by the United States Department of State noted serious concerns over human rights violations by the government and militia groups. Capital punishment, including crucifixion, is used for many crimes. In September, 2019, the government of Sudan signed an agreement with the UN High Commissioner for Human Rights to open a UN Human Rights Office in Khartoum and field offices in Darfur, Blue Nile, Southern Kordofan and East Sudan. In July 2020, during the 2019–2021 Sudanese transition to democracy, Justice Minister Nasredeen Abdulbari stated that "all the laws violating the human rights in Sudan" were to be scrapped, and for this reason, Parliament passed a series of laws in early July 2020.

Islamic extremism is characterised by extremist beliefs, behaviors and ideologies adhered to by some Muslims within Islam. The term 'Islamic extremism' is contentious, encompassing a spectrum of definitions, ranging from academic interpretations of Islamic supremacy to the notion that all ideologies other than Islam have failed and are inferior.