Northwest Indian War: The Western Confederacy of American Indians wins a major victory over the United States in the Battle of the Wabash.

The Northwest Indian War (1785–1795), also known by other names, was an armed conflict for control of the Northwest Territory fought between the United States and a united group of Native American nations known today as the Northwestern Confederacy. The United States Army considers it the first of the American Indian Wars.

The Northwestern Confederacy, or Northwestern Indian Confederacy, was a loose confederacy of Native Americans in the Great Lakes region of the United States created after the American Revolutionary War. Formally, the confederacy referred to itself as the United Indian Nations, at their Confederate Council. It was known infrequently as the Miami Confederacy since many contemporaneous federal officials overestimated the influence and numerical strength of the Miami tribes based on the size of their principal city, Kekionga.

Native Americans are the Indigenous peoples of the United States, particularly of the lower 48 states and Alaska. They may also include any Americans whose origins lie in any of the indigenous peoples of North or South America. The United States Census Bureau publishes data about "American Indians and Alaska Natives", whom it defines as anyone "having origins in any of the original peoples of North and South America ... and who maintains tribal affiliation or community attachment". The census does not, however, enumerate "Native Americans" as such, noting that the latter term can encompass a broader set of groups, e.g. Native Hawaiians, which it tabulates separately.

St. Clair's defeat, also known as the Battle of the Wabash, the Battle of Wabash River or the Battle of a Thousand Slain, was a battle fought on 4 November 1791 in the Northwest Territory of the United States. The U.S. Army faced the Northwestern Confederacy of Native Americans as part of the Northwest Indian War. It was "the most decisive defeat in the history of the American military" and its largest defeat ever by Native Americans.