The Holocaust: The Gestapo conducted a raid on the Roman Ghetto, capturing 1,259 members of the Jewish community, most of whom were sent to Auschwitz.

The Holocaust, known in Hebrew as the Shoah, was the genocide of European Jews during World War II. From 1941 to 1945, Nazi Germany and its collaborators systematically murdered some six million Jews across German-occupied Europe, around two-thirds of Europe's Jewish population. The murders were committed primarily through mass shootings across Eastern Europe and poison gas chambers in extermination camps, chiefly Auschwitz-Birkenau, Treblinka, Belzec, Sobibor, and Chełmno in occupied Poland. Separate Nazi persecutions killed millions of other non-Jewish civilians and prisoners of war (POWs); the term Holocaust is sometimes used to include the murder and persecution of non-Jewish groups.

The Geheime Staatspolizei, abbreviated Gestapo ( ), was the official secret police of Nazi Germany and in German-occupied Europe.

The raid on the Roman Ghetto took place on 16 October 1943. A total of 1,259 people, mainly members of the Jewish community—numbering 363 men, 689 women, and 207 children—were detained by the Gestapo. Of these detainees, 1,023 were identified as Jews and deported to the Auschwitz concentration camp. Of these deportees, only fifteen men and one woman survived.

The Roman Ghetto or Ghetto of Rome was a Jewish ghetto established in 1555 by Pope Paul IV in the Rione Sant'Angelo, in Rome, Italy, in the area surrounded by present-day Via del Portico d'Ottavia, Lungotevere dei Cenci, Via del Progresso and Via di Santa Maria del Pianto, close to the River Tiber and the Theatre of Marcellus. With the exception of brief periods under Napoleon from 1808 to 1815 and under the Roman Republics of 1798–99 and 1849, the ghetto of Rome was controlled by the papacy until the capture of Rome in 1870.