Florence Nightingale and a staff of 38 nurses are sent to the Crimean War.

Florence Nightingale was an English social reformer, statistician and the founder of modern nursing. Nightingale came to prominence while serving as a manager and trainer of nurses during the Crimean War, in which she organised care for wounded soldiers at Constantinople. She significantly reduced death rates by improving hygiene and living standards. Nightingale gave nursing a favourable reputation and became an icon of Victorian culture, especially in the persona of "The Lady with the Lamp" making rounds of wounded soldiers at night.

The Crimean War was fought between the Russian Empire and an alliance of the Ottoman Empire, the Second French Empire, the United Kingdom of Great Britain and Ireland, and the Kingdom of Sardinia-Piedmont from October 1853 to February 1856. Geopolitical causes of the war included the "Eastern question", expansion of Imperial Russia in the preceding Russo-Turkish wars, and the British and French preference to preserve the Ottoman Empire to maintain the balance of power in the Concert of Europe.