Major Rudolf Anderson of the United States Air Force becomes the only direct human casualty of the Cuban Missile Crisis when his U-2 reconnaissance airplane is shot down over Cuba by a Soviet-supplied surface-to-air missile.

Rudolf Anderson Jr. was an American Air Force major and pilot. He was the first recipient of the Air Force Cross, the U.S. military's and Air Force's second-highest award and decoration for valor. The only U.S. fatality by enemy fire during the Cuban Missile Crisis, Anderson was killed when his U-2 reconnaissance aircraft was shot down over Cuba. He had previously served in Korea during the Korean War.

The Cuban Missile Crisis, also known as the October Crisis in Cuba, or the Caribbean Crisis, was a 13-day confrontation between the governments of the United States and the Soviet Union, when American deployments of nuclear missiles in Italy and Turkey were matched by Soviet deployments of nuclear missiles in Cuba. The crisis lasted from 16 to 28 October 1962. The confrontation is widely considered the closest the Cold War came to escalating into full-scale nuclear war.