Second Ottoman–Mamluk War: Mamluks fail to stop the Ottoman advance towards Egypt at the Battle of Yaunis Khan.

The Ottoman–Mamluk War of 1516–1517 was the second major conflict between the Egypt-based Mamluk Sultanate and the Ottoman Empire, which led to the Fall of the Mamluk Sultanate and the incorporation of the Levant, Egypt, and the Hejaz as provinces of the Ottoman Empire. The war transformed the Ottoman Empire from a realm at the margins of the Islamic world, mainly located in Anatolia and the Balkans, to a huge empire encompassing much of the traditional lands of Islam, including the cities of Mecca, Cairo, Damascus, and Aleppo. Despite this expansion, the seat of the empire's political power remained in Constantinople.

The Battle of Yaunis Khan, also known as the Battle of Khan Yunis, was fought on October 28, 1516, between the Ottoman Empire and the Mamluk Sultanate. The Mamluk cavalry forces led by Janbirdi al-Ghazali attacked the Ottomans that were trying to cross Gaza on their way to Egypt. The Ottomans, led by Grand Vizier Hadım Sinan Pasha, were able to break the Egyptian Mamluk cavalry charge. Al-Ghazali was wounded during the confrontation, and the left-over Mamluk forces and their commander Al-Ghazali retreated to Cairo.