Mir EO-19, the first expedition to the Russian space station Mir launched on an American Space Shuttle, returned to Earth after approximately 75 days in space.

Mir EO-19 was the nineteenth crewed expedition to the space station Mir, lasting from June to September 1995. The crew, consisting of Russian cosmonauts Anatoly Solovyev and Nikolai Budarin, launched on June 27, 1995, aboard the Space Shuttle Atlantis on the STS-71 mission. After remaining aboard Mir for approximately 75 days, Solovyev and Budarin returned aboard the Soyuz TM-21 spacecraft on September 11, 1995.

Mir was a space station operated in low Earth orbit from 1986 to 2001, first by the Soviet Union and later by the Russian Federation. Mir was the first modular space station and was assembled in orbit from 1986 to 1996. It had a greater mass than any previous spacecraft. At the time it was the largest artificial satellite in orbit, succeeded by the International Space Station (ISS) after Mir's orbit decayed. The station served as a microgravity research laboratory in which crews conducted experiments in biology, human biology, physics, astronomy, meteorology, and spacecraft systems with a goal of developing technologies required for permanent occupation of space.

The Space Shuttle is a retired, partially reusable low Earth orbital spacecraft system operated from 1981 to 2011 by the U.S. National Aeronautics and Space Administration (NASA) as part of the Space Shuttle program. Its official program name was the Space Transportation System (STS), taken from the 1969 plan led by U.S. vice president Spiro Agnew for a system of reusable spacecraft where it was the only item funded for development.