The second of two major uprisings by the Old Prussians, a Baltic tribe, began against the Teutonic Knights.

The Prussian uprisings were two major and three smaller uprisings by the Old Prussians, one of the Baltic tribes, against the Teutonic Knights that took place in the 13th century during the Prussian Crusade. The crusading military order, supported by the Popes and Christian Europe, sought to conquer and convert the pagan Prussians. In the first ten years of the crusade, five of the seven major Prussian clans fell under the control of the less numerous Teutonic Knights. However, the Prussians rose against their conquerors on five occasions.

Old Prussians, Baltic Prussians or simply Prussians were a Baltic people that inhabited the region of Prussia, on the southeastern shore of the Baltic Sea between the Vistula Lagoon to the west and the Curonian Lagoon to the east. As Balts, they spoke an Indo-European language of the Baltic branch now known as Old Prussian and worshipped pre-Christian deities. Their ethnonym was later adopted by predominantly Low German-speaking inhabitants of the region.

The Balts or Baltic peoples are a group of peoples inhabiting the eastern coast of the Baltic Sea who speak Baltic languages. Among the Baltic peoples are modern-day Lithuanians and Latvians — all East Balts — as well as the Old Prussians, Curonians, Sudovians, Skalvians, Yotvingians and Galindians — the West Balts — whose languages and cultures are now extinct, but made a large influence on the living branches, especially on literary Lithuanian language.

The Teutonic Order is a Catholic religious institution founded as a military society c. 1190 in Acre, Kingdom of Jerusalem. The Order of Brothers of the German House of Saint Mary in Jerusalem was formed to aid Christians on their pilgrimages to the Holy Land and to establish hospitals. Its members have commonly been known as the Teutonic Knights, having historically served as a crusading military order for supporting Catholic rule in the Holy Land and the Northern Crusades during the Middle Ages, as well as supplying military protection for Catholics in Eastern Europe.