The first attacks of the Tuscarora War begin in present-day North Carolina.

The Tuscarora War was fought in North Carolina from September 10, 1711, until February 11, 1715, between the Tuscarora people and their allies on one side and European American settlers, the Yamasee, and other allies on the other. This was considered the bloodiest colonial war in North Carolina. The Tuscarora signed a treaty with colonial officials in 1718 and settled on a reserved tract of land in Bertie County, North Carolina. The war incited further conflict on the part of the Tuscarora and led to changes in the slave trade of North and South Carolina.

North Carolina is a state in the Southeastern region of the United States. It is bordered by Virginia to the north, the Atlantic Ocean to the east, South Carolina to the south, Georgia to the southwest, and Tennessee to the west. The state is the 28th-largest and 9th-most populous of the United States. Along with South Carolina, it makes up the Carolinas region of the East Coast. At the 2020 census, the state had a population of 10,439,388. Raleigh is the state's capital and Charlotte is its most populous and one of the fastest growing cities in the United States. The Charlotte metropolitan area, with an estimated population of 2,883,370 in 2024, is the most populous metropolitan area in North Carolina, the 21st-most populous in the United States, and the largest banking center in the nation after New York City. The Research Triangle, with an estimated population of 2,368,947 in 2023, is the second-most populous combined metropolitan area in the state, 31st-most populous in the United States, and is home to the largest research park in the United States, Research Triangle Park.

September 22 is the 265th day of the year in the Gregorian calendar; 100 days remain until the end of the year.