PSA Flight 182, a Boeing 727, collides in mid-air with a Cessna 172 and crashes in San Diego, killing all 135 aboard Flight 182, both occupants of the Cessna, as well as seven people on the ground.

Pacific Southwest Airlines Flight 182 was a scheduled flight on September 25, 1978 by Pacific Southwest Airlines (PSA), from Sacramento to San Diego (SAN), with a stopover at Los Angeles (LAX). The aircraft involved was a Boeing 727-214, collided mid-air with a private Cessna 172 over San Diego. It was Pacific Southwest Airlines' first fatal accident and it remains the deadliest air disaster in California history. At the time, it was the deadliest air crash to occur in the United States and remained so until the crash of American Airlines Flight 191 in May 1979. Excluding intentional crashes, it currently stands as the seventh-deadliest to occur on American soil.

September 25 is the 268th day of the year in the Gregorian calendar; 97 days remain until the end of the year.