The Kyshtym disaster is the third-worst nuclear accident ever recorded.

The Kyshtym disaster,, sometimes referred to as the Mayak disaster or Ozyorsk disaster in newer sources, was a radioactive contamination accident that occurred on 29 September 1957 at Mayak, a plutonium reprocessing production plant for nuclear weapons located in the closed city of Chelyabinsk-40 in Chelyabinsk Oblast, Russia in the Soviet Union.

A nuclear and radiation accident is defined by the International Atomic Energy Agency (IAEA) as "an event that has led to significant consequences to people, the environment or the facility." Examples include lethal effects to individuals, large radioactivity release to the environment, or a reactor core melt. The prime example of a "major nuclear accident" is one in which a reactor core is damaged and significant amounts of radioactive isotopes are released, such as in the Chernobyl disaster in 1986 and Fukushima nuclear accident in 2011.

September 29 is the 272nd day of the year in the Gregorian calendar; 93 days remain until the end of the year.