Ten people are killed and 15 are injured in a stabbing spree in 13 locations on the James Smith Cree Nation and in Weldon, Saskatchewan.

On September 4, 2022, Myles Sanderson killed 11 and injured 17 people in a mass stabbing at 13 locations on the James Smith Cree Nation and in Weldon, Saskatchewan, Canada. Some of the victims are believed to have been targeted, while others were randomly attacked. It is one of the deadliest massacres in Canadian history.

The James Smith First Nation is a Plains Cree Indigenous band government whose reserve is north of Melfort, Saskatchewan, Canada. James Smith has two reserves, James Smith 100 and Cumberland 100A. James Smith has a current population of 2,412, with the on-reserve population estimated to be at 1,592 members. James Smith is part of the Prince Albert Grand Council. Bordering the reserve are the rural municipalities of Kinistino No. 459 and Torch River No. 488.

Weldon is a village in the Canadian province of Saskatchewan within the Rural Municipality of Kinistino No. 459 and Census Division No. 15. The area is part of the aspen parkland biome. The village is located 2 km (1.2 mi) north of Highway 3 at the midway point between the cities of Prince Albert and Melfort, Saskatchewan. The village is just 20 km (12 mi) south of the Weldon Ferry linking it to Highway 302 and is often used as an access point to the historic Saskatchewan River Forks where the North and South Saskatchewan rivers join just 25 km (16 mi) to the northeast.

September 4 is the 247th day of the year in the Gregorian calendar; 118 days remain until the end of the year.