The Great Galveston hurricane, the deadliest natural disaster in U.S. history, struck Galveston, Texas, with estimated winds of 135 miles per hour (215 km/h) at landfall, killing at least 6,000 people.

The 1900 Galveston hurricane, also known as the Great Galveston hurricane and the Galveston Flood, and known regionally as the Great Storm of 1900 or the 1900 Storm, was a catastrophic tropical cyclone that became the deadliest natural disaster in the history of the United States. The strongest storm of the 1900 Atlantic hurricane season, it left between 6,000 and 12,000 fatalities in the United States; the number most cited in official reports is 8,000. Most of these deaths occurred in and near Galveston, Texas, after the storm surge inundated the coastline and the island city with 8 to 12 ft of water. As of 2025, it remains the fourth deadliest Atlantic hurricane on record, behind Hurricane Fifi of 1974. In addition to the number killed, the storm destroyed about 7,000 buildings of all uses in Galveston, which included 3,636 demolished homes; every dwelling in the city suffered some degree of damage. The hurricane left approximately 10,000 people in the city homeless, out of a total population of fewer than 38,000. The disaster ended the Golden Era of Galveston. The hurricane alarmed potential investors, who turned to Houston instead. In response to the storm, three engineers designed and oversaw plans to raise the Gulf of Mexico shoreline of Galveston Island by 17 ft (5.2 m) and erect a 10 mi (16 km) seawall.

This list of United States disasters by death toll includes disasters that occurred either in the United States, at diplomatic missions of the United States, or incidents outside of the United States in which a number of U.S. citizens were killed.

• Domestic deaths due to war in America are included except the American Civil War. For stats on this and U.S. military deaths in foreign locations, see United States military casualties of war and list of battles with most United States military fatalities.
• Due to inflation, the monetary damage estimates are not comparable. Unless otherwise noted, the year given is the year in which the currency's valuation was calculated.

Galveston is a coastal resort city and port off the Southeast Texas coast on Galveston Island and Pelican Island in the U.S. state of Texas. The community of 211.31 square miles (547.3 km²), with a population of 53,695 at the 2020 census, is the county seat of surrounding Galveston County and second-largest municipality in the county. It is also within the Houston–The Woodlands–Sugar Land metropolitan area at its southern end on the northwestern coast of the Gulf of Mexico.