Isaac Low, American merchant and politician, founded the New York Chamber of Commerce (died 1791)

Isaac Low was an American merchant in New York City who served as a member of the Continental Congress, where he signed the Continental Association. He later served as a delegate to the New York Provincial Congress. Though originally a Patriot, he later joined the Loyalist cause in the American Revolution.

The New York Chamber of Commerce was founded in 1768 by twenty New York City merchants. As the first such commercial organization in the United States, it attracted the participation of a number of New York's most influential business leaders, including John Jacob Astor, Peter Cooper, and J. Pierpont Morgan. The chamber's members were instrumental in the realization of several key initiatives in the region – including the Erie Canal, the Atlantic cable, and the New York City Transit Authority. The Chamber of Commerce survives today as the Partnership for New York City, which was formed from the 2002 merger of the New York Chamber of Commerce and Industry and the New York City Partnership.