An earthquake kills about 5,000 people in Gargano, Italy.

The 1627 Gargano earthquake struck Gargano and part of Tavoliere, southern Italy, at about mid-day on 30 July 1627. A "very large earthquake" caused a major tsunami, the largest seismic event ever recorded in the Gargano region, which "produced severe damage in the whole promontory", killing about 5,000 people. Four aftershocks were documented. The most extensive damage was noted between San Severo and Lesina.

Gargano is a historical and geographical sub-region in the province of Foggia, Apulia, southeast Italy, consisting of a wide isolated mountain massif made of highland and several peaks and forming the backbone of a promontory projecting into the Adriatic Sea, the "spur" on the Italian "boot".

July 30 is the 211th day of the year in the Gregorian calendar; 154 days remain until the end of the year.