Believing he had reached the East Indies, Christopher Columbus made landfall on an island in the Caribbean, sparking a series of events that led to the European colonization of the Americas.

The East Indies is a term used in historical narratives of the Age of Discovery. The Indies broadly referred to various lands in the East or the Eastern Hemisphere, particularly the islands and mainlands found in and around the Indian Ocean by Portuguese explorers, soon after the Cape Route was discovered. In a narrow sense, the term was used to refer to the Malay Archipelago, which today comprises the Philippine Archipelago, Indonesian Archipelago, Borneo, and New Guinea. Historically, the term was used in the Age of Discovery to refer to the coasts of the landmasses comprising the Indian subcontinent and the Indochinese Peninsula along with the Malay Archipelago.

Christopher Columbus was an Italian explorer and navigator from the Republic of Genoa who completed four Spanish-based voyages across the Atlantic Ocean sponsored by the Catholic Monarchs, opening the way for the widespread European exploration and colonization of the Americas. His expeditions were the first known European contact with the Caribbean and Central and South America.

The Caribbean is a region in the middle of the Americas centered around the Caribbean Sea in the North Atlantic Ocean, mostly overlapping with the West Indies. Bordered by North America to the north, Central America to the west, and South America to the south, it comprises numerous islands, cays, islets, reefs, and banks.

During the Age of Discovery, a large scale colonization of the Americas, involving European countries, took place primarily between the late 15th century and early 19th century. The Norse settled areas of the North Atlantic, colonizing Greenland and creating a short-term settlement near the northern tip of Newfoundland circa 1000 AD. However, due to its long duration and importance, the later colonization by Europeans, after Christopher Columbus’s voyages, is more well-known. During this time, the European colonial empires of Spain, Portugal, Great Britain, France, Russia, the Netherlands, Denmark, and Sweden began to explore and claim the Americas, its natural resources, and human capital, leading to the displacement, disestablishment, enslavement, and genocide of the Indigenous peoples in the Americas, and the establishment of several settler colonial states.